Point-of-care procalcitonin trends in suspected neonatal late-onset infection: a prospective observational study | Pediatric Research

Oct 26, 2024

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Procalcitonin-guided antimicrobial decision-making has been shown to be safe in adult intensive care settings. Most antimicrobial exposure in neonatal units is in culture-negative conditions. We hypothesise that Procalcitonin aids antimicrobial stewardship efforts in suspected Late-Onset Neonatal Sepsis.

Neonates were enrolled if they were aged over 72 h and were placed on antibiotics for a suspected infection. Procalcitonin levels were taken at set timepoints for the duration of antimicrobial exposure. Three subgroups were created: non-infectious episodes, blood culture-negative infectious episodes, and bloodstream infections.

Eighty-five suspected infectious episodes were recruited across two tertiary neonatal and paediatric intensive care units. There was a significant difference between the median PCT in bloodstream infections (BSI) compared to non-infectious episodes (2.13 versus 0.26 µg/L, p < 0.001). A cut-off of 0.5 µg/L had sensitivity 92.9% and specificity 68% for bloodstream infections at 24 h. The difference between median PCT values at 24 h was significant (0.27 vs 7.08; p < 0.001) for feed intolerance vs. NEC Grade IIIa-IIIb subgroups.

Procalcitonin levels taken 24 h following evaluation for late-onset neonatal infection are useful in out ruling BSI or severe Necrotising Enterocolitis. Up to 30% of antimicrobial exposure could be avoided with the use of Procalcitonin levels in low-risk neonates.

This study demonstrates the utility of serial Procalcitonin measurements in antimicrobial stewardship efforts in the Neonatal Unit.

Procalcitonin can be used to aid in antimicrobial decision making in suspected Late-Onset neonatal infection.

Procalcitonin testing at twenty-four hours in episodes of Gastrointestinal deterioration can out rule Bells Grade III Necrotising Enterocolitis.

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The datasets generated during and/or analysed during the current study are not publicly available due GDPR restrictions but are available from the corresponding author on reasonable request.

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This research was enabled by a researcher salary grant from the Rotunda Foundation. (RF/NICU/2020/01)

Rotunda Hospital, Dublin, Ireland

Sean J. Armstrong & Adrienne Foran

Department of Clinical Biochemistry, Children’s Health Ireland, Dublin, Ireland

Jennifer J. Brady

University College Dublin School of Medicine, Dublin, Ireland

Jennifer J. Brady

Irish Meningitis and Sepsis Reference Laboratory, Children’s Health Ireland, Dublin, Ireland

Richard J. Drew

Clinical Innovation Unit, Rotunda Hospital, Dublin, Ireland

Richard J. Drew

Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland

Richard J. Drew

Department of Paediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland

Adrienne Foran

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Sean Armstrong, Jennifer Brady, Richard Drew, and Adrienne Foran all made substantial contributions to conception, design, analysis, and interpretation of data. Sean Armstrong also acquired all data for the study, drafted the article and takes responsibility for final approval of the published version. Jennifer Brady, Richard Drew, and Adrienne Foran all critically reviewed the article and have taken responsibility for final approval of the published version.

Correspondence to Sean J. Armstrong.

The authors declare no competing interests.

Written information leaflets were presented to caregivers of all infants approached for study recruitment. Written consent was obtained prior to recruitment in the study.

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Armstrong, S.J., Brady, J.J., Drew, R.J. et al. Point-of-care procalcitonin trends in suspected neonatal late-onset infection: a prospective observational study. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03670-x

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Received: 14 June 2024

Revised: 23 September 2024

Accepted: 04 October 2024

Published: 25 October 2024

DOI: https://doi.org/10.1038/s41390-024-03670-x

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